Poly(N-isopropylacrylamide)_(PNIPAM)

polymer

Poly(N-isopropylacrylamide) or PNIPAM is a synthetic polymer notable for its temperature-responsive behavior, exhibiting a sharp phase transition in aqueous solutions near body temperature that causes it to switch between hydrophilic and hydrophobic states. While primarily a research material rather than an established industrial commodity, PNIPAM is actively investigated for biomedical and pharmaceutical applications where controlled, reversible responses to temperature changes can enable drug delivery, cell culture platforms, and diagnostic systems without chemical triggers. Engineers select PNIPAM when designing smart polymer systems that require autonomous switching behavior or stimuli-responsive performance in biological environments.

stimuli-responsive drug deliverysmart biomaterials (research stage)temperature-triggered cell culture systemsbiosensing and diagnosticsbiomedical coatings and hydrogelsexperimental polymer research

Compliance & Regulations

?UL 94?Conflict Free?RoHS?REACH?TSCA?Prop 65

Units:

si imperial

Property	Value	Unit	Conditions	Source
Glass Transition Temperature(Tg)	225.2	°F	—

Verified Unverified Low confidence (<80%) Link to source

Regulatory Screening

Environmental

Safety & Biocompatibility

RoHS, REACH, and Prop 65 statuses are validated against official substance lists (ECHA SVHC Candidate List, OEHHA Prop 65, RoHS Annex II). Other regulations are estimated from composition and material classification. All screening is a starting point for due diligence — always verify with your supplier before making compliance decisions.

Poly(N-isopropylacrylamide)_(PNIPAM)

Thermal Properties

Regulatory Screening

Environmental

Safety & Biocompatibility