Bioglass 45S5

Bioglass 45S5 is a silicate-based bioactive ceramic composed of silica, sodium oxide, calcium oxide, and phosphorus oxide that bonds directly to living bone and soft tissue through formation of a hydroxyapatite layer when in contact with biological fluids. It is widely used in orthopedic and dental applications—including bone void fillers, dental implants, periodontal regeneration, and maxillofacial reconstruction—because it promotes osteogenic (bone-forming) response and integrates with native tissue rather than remaining inert like traditional ceramics. Engineers select Bioglass 45S5 when biological integration and resorption are design goals, distinguishing it from inert alumina or zirconia ceramics that encapsulate rather than bond with bone.